First of all, DOS manages memory in units of paragraphs (16 bytes), not individual bytes. This approach is derived from the segmented 8086 architecture. Managing memory in paragraph units allows DOS to use 16-bit quantities to record the starting address and size of each block. In addition, the starting paragraph address is also implicitly the segment address of the block. Note that due to tracking sizes in terms of paragraphs, DOS memory blocks are not limited to 64K.
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The Boy With Wings