Scientists created an exam so broad, challenging and deeply rooted in expert human knowledge that current AI systems consistently fail it. “Humanity’s Last Exam” introduces 2,500 questions spanning mathematics, humanities, natural sciences, ancient languages and highly specialized subfields.

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SSIM (Structural Similarity Index Measure) compares two images by evaluating luminance, contrast, and structural patterns across local windows. It returns a score from -1 to 1: 1.0 means the images are pixel-identical, 0 means no structural correlation, and negative values mean the images are anti-correlated (less alike than random noise). For glyph comparison, it answers the question: do these two rendered characters share the same visual structure?

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Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21